Chronic Hypoxia Emerging as One of the Driving Forces behind Gene Expression and Prognosis of Hepatocellular Carcinoma
Joint Authors
Verslype, Chris
Nevens, Frederik
van Malenstein, Hannah
van Pelt, Jos F.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors and an important cause of death.
It has become evident that the tumor microenvironment, including hypoxia, plays a major role in the development of HCC.
This paper focuses on the role of chronic hypoxia in HCC.
Recently, we have shown the importance of chronic hypoxia on gene expression and behavior of liver cells.
Using a cell culture model, we identified a distinct gene expression pattern and demonstrated clinical relevance for a 7-gene subset that can predict survival and early recurrence in patients.
Recently, it was also shown that chronic hypoxia is associated with the upregulation of β-catenin and Hif1α and that suppression of β-catenin reduced the metastatic potential of the tumor.
Both studies demonstrate the importance of chronic hypoxia for the prognosis of HCC.
Identifying the molecular pathways can help us to understand the mechanisms responsible for tumor aggressiveness.
American Psychological Association (APA)
van Pelt, Jos F.& van Malenstein, Hannah& Nevens, Frederik& Verslype, Chris. 2011. Chronic Hypoxia Emerging as One of the Driving Forces behind Gene Expression and Prognosis of Hepatocellular Carcinoma. ISRN Pathology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-459421
Modern Language Association (MLA)
van Pelt, Jos F.…[et al.]. Chronic Hypoxia Emerging as One of the Driving Forces behind Gene Expression and Prognosis of Hepatocellular Carcinoma. ISRN Pathology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-459421
American Medical Association (AMA)
van Pelt, Jos F.& van Malenstein, Hannah& Nevens, Frederik& Verslype, Chris. Chronic Hypoxia Emerging as One of the Driving Forces behind Gene Expression and Prognosis of Hepatocellular Carcinoma. ISRN Pathology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-459421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459421