Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease
Joint Authors
Torres, Vicente E.
Chen, Jey-Hsin
Eggleston-Gulyas, Tracy
Haydon, Julie
Gattone, Vincent
Wang, Xiaofang
Blazer-Yost, Bonnie L.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Polycystic kidney disease (PKD) is a genetic disorder characterized by growth of fluid-filled cysts predominately in kidney tubules and liver bile ducts.
Currently, the clinical management of PKD is limited to cyst aspiration, surgical resection or organ transplantation.
Based on an observation that PPARγ agonists such as pioglitazone and rosiglitazone decrease mRNA levels of a Cl− transport protein, CFTR (cystic fibrosis transmembrane conductance regulator), and the Cl− secretory response to vasopressin in cultured renal cells, it is hypothesized that PPARγ agonists will inhibit cyst growth.
The current studies show that a 7- or 14-week pioglitazone feeding regimen inhibits renal and hepatic bile duct cyst growth in the PCK rat, a rodent model orthologous to human PKD.
These studies provide proof of concept for the mechanism of action of the PPARγ agonists and suggest that this class of drugs may be effective in controlling both renal and hepatic cyst growth and fibrosis in PKD.
American Psychological Association (APA)
Blazer-Yost, Bonnie L.& Haydon, Julie& Eggleston-Gulyas, Tracy& Chen, Jey-Hsin& Wang, Xiaofang& Gattone, Vincent…[et al.]. 2010. Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease. PPAR Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-459457
Modern Language Association (MLA)
Blazer-Yost, Bonnie L.…[et al.]. Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease. PPAR Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-459457
American Medical Association (AMA)
Blazer-Yost, Bonnie L.& Haydon, Julie& Eggleston-Gulyas, Tracy& Chen, Jey-Hsin& Wang, Xiaofang& Gattone, Vincent…[et al.]. Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-459457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459457