Adjuvant Therapy : Melanoma
Joint Authors
Kirkwood, John M.
Tarhini, Ahmad
Davar, Diwakar
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-19
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
With an incidence that is increasing at 2–5% per year, cutaneous melanoma is an international scourge that disproportionately targets young individuals.
Despite much research, the treatment of advanced disease is still quite challenging.
Immunotherapy with high-dose interferon-α2b or interleukin-2 benefits a select group of patients in the adjuvant and metastatic settings, respectively, with significant attendant toxicity.
Advances in the biology of malignant melanoma and the role of immunomodulatory therapy have produced advances that have stunned the field.
In this paper, we review the data for the use of interferon-α2b in various dosing ranges, vaccine therapy, and the role of radiotherapy in the adjuvant setting for malignant melanoma.
Recent trials in the metastatic setting using anticytoxic T-lymphocyte antigen-4 (anti-CTLA-4) monoclonal antibody therapy and BRAF inhibitor therapy have demonstrated clear benefit with prolongation of survival.
Trials investigating combinations of these novel agents with existing immunomodulators are at present underway.
American Psychological Association (APA)
Davar, Diwakar& Tarhini, Ahmad& Kirkwood, John M.. 2011. Adjuvant Therapy : Melanoma. Journal of Skin Cancer،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-459460
Modern Language Association (MLA)
Davar, Diwakar…[et al.]. Adjuvant Therapy : Melanoma. Journal of Skin Cancer No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-459460
American Medical Association (AMA)
Davar, Diwakar& Tarhini, Ahmad& Kirkwood, John M.. Adjuvant Therapy : Melanoma. Journal of Skin Cancer. 2011. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-459460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459460