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The Haematopoietic Stem Cell Niche : New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour
Joint Authors
Lilly, Andrew J.
Johnson, William E.
Bunce, Christopher M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the 1970s, as a region within the bone marrow containing functional cell types that can maintain HSC potency throughout life.
Since then, ongoing research has identified numerous cell types and a plethora of signals that not only maintain HSCs, but also dictate their behaviour with respect to homeostatic requirements and exogenous stresses.
It has been proposed that there are endosteal and vascular niches within the bone marrow, which are thought to regulate different HSC populations.
However, recent data depicts a more complicated picture, with functional crosstalk between cells in these two regions.
In this review, recent research into the endosteal/vascular cell types and signals regulating HSC behaviour are considered, together with the possibility of a single subcompartmentalised niche.
American Psychological Association (APA)
Lilly, Andrew J.& Johnson, William E.& Bunce, Christopher M.. 2011. The Haematopoietic Stem Cell Niche : New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour. Stem Cells International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-459466
Modern Language Association (MLA)
Lilly, Andrew J.…[et al.]. The Haematopoietic Stem Cell Niche : New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour. Stem Cells International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-459466
American Medical Association (AMA)
Lilly, Andrew J.& Johnson, William E.& Bunce, Christopher M.. The Haematopoietic Stem Cell Niche : New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-459466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459466