What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?
Joint Authors
Dubus, I.
Schneider, P.
Vannier, J. P.
Legrand, E.
Gouel, F.
Vasse, M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The role of angiogenesis in acute leukaemia has been discussed since the cloning of the gene of vascular endothelial growth factor (VEGF) from the acute myelogenous leukemia cell line (HL60) and, thereafter, when the first studies reported increased bone marrow vascularity and elevation of angiogenic cytokines in acute lymphoblastic leukaemia (ALL).
VEGF and basic fibroblast growth factor (bFGF) are the major proangiogenic cytokines that have been studied, and evaluation of their prognostic impact in childhood ALL has been reported in several studies, though with controversial results.
The antiangiogenic response, contributing to the angiogenic balance, has scarcely been reported.
The origin of the factors, their prognostic value, and their relevance as good markers of what really happens in the bone marrow are discussed in this paper.
The place of antiangiogenic drugs in ALL has to be defined in the global treatment strategy.
American Psychological Association (APA)
Schneider, P.& Dubus, I.& Gouel, F.& Legrand, E.& Vannier, J. P.& Vasse, M.. 2011. What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?. Advances in Hematology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-459476
Modern Language Association (MLA)
Schneider, P.…[et al.]. What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?. Advances in Hematology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-459476
American Medical Association (AMA)
Schneider, P.& Dubus, I.& Gouel, F.& Legrand, E.& Vannier, J. P.& Vasse, M.. What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?. Advances in Hematology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-459476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459476