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Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes
Joint Authors
Pawłowski, Przemysław
Szczepaniak, Izabela
Bossowski, Artur
Bakunowicz-Łazarczyk, Alina
Wójtowicz, Jerzy
Semeran, Kornel
Ławicki, Sławomir
Lisowski, Łukasz
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The study objective was to assess chosen biochemical parameters of blood and bioelectric function of the retina in patients with T1DM.
The study group consisted of 41 patients with T1DM with no signs of diabetic retinopathy.
The control group included 21 pediatric patients.
We performed (1) S-cone ERG testing with retina response stimulation in both eyes at the luminance of 0.1, 0.2, and 0.5 (cd × s/m2) with the 440 nm blue flash and light application of the amber background (300 ph cd/m2, 495 nm wavelength), (2) anthropometric measurements, (3) biochemical investigations: IL-17, VEGF, and ADM by the ELISA method.
A comparison of the ERG results with biochemical investigations indicates a likely correlation between the worsening of retinal bioelectric function and VEGF levels growing with diabetes duration.
We showed a negative correlation between ADM and HbA1c and described possible causes of ADM reduction observed in subgroup I.
We demonstrated the presence of bioelectric retinal dysfunction already before the diagnosis of diabetic retinopathy, which provides new possibilities in the diagnosis of preclinical chronic complications of diabetes.
The changes observed in the levels of IL-17, ADM, and VEGF suggest their involvement in the diabetic pathogenesis of eye diseases.
American Psychological Association (APA)
Semeran, Kornel& Pawłowski, Przemysław& Lisowski, Łukasz& Szczepaniak, Izabela& Wójtowicz, Jerzy& Ławicki, Sławomir…[et al.]. 2013. Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-459483
Modern Language Association (MLA)
Semeran, Kornel…[et al.]. Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-459483
American Medical Association (AMA)
Semeran, Kornel& Pawłowski, Przemysław& Lisowski, Łukasz& Szczepaniak, Izabela& Wójtowicz, Jerzy& Ławicki, Sławomir…[et al.]. Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-459483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459483