Anxiolytic and Anticonvulsant Effects on Mice of Flavonoids, Linalool, and α-Tocopherol Presents in the Extract of Leaves of Cissus sicyoides L. (Vitaceae)
Joint Authors
Ishigami, Ana Beatriz Matos
Couto, Geraldo Bosco Lindoso
Almeida, Edvaldo Rodrigues de
Rafael, Krissia Rayane de Oliveira
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts of Cissus sicyoides L.
(CS) (Vitaceae) on male and female mice using several behavioral assays.
Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms.
The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried.
The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions.
These results indicate an anxiolytic and anticonvulsant-like action from C.
sicyoides L.
extract on mice, probably due to the action of flavonoid(s), Linalool, and α-tocopherol present in the C.
sicyoides leaves.
American Psychological Association (APA)
Almeida, Edvaldo Rodrigues de& Rafael, Krissia Rayane de Oliveira& Couto, Geraldo Bosco Lindoso& Ishigami, Ana Beatriz Matos. 2009. Anxiolytic and Anticonvulsant Effects on Mice of Flavonoids, Linalool, and α-Tocopherol Presents in the Extract of Leaves of Cissus sicyoides L. (Vitaceae). Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-459488
Modern Language Association (MLA)
Almeida, Edvaldo Rodrigues de…[et al.]. Anxiolytic and Anticonvulsant Effects on Mice of Flavonoids, Linalool, and α-Tocopherol Presents in the Extract of Leaves of Cissus sicyoides L. (Vitaceae). Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-459488
American Medical Association (AMA)
Almeida, Edvaldo Rodrigues de& Rafael, Krissia Rayane de Oliveira& Couto, Geraldo Bosco Lindoso& Ishigami, Ana Beatriz Matos. Anxiolytic and Anticonvulsant Effects on Mice of Flavonoids, Linalool, and α-Tocopherol Presents in the Extract of Leaves of Cissus sicyoides L. (Vitaceae). Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-459488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459488