![](/images/graphics-bg.png)
Role of PIR-B in Autoimmune Glomerulonephritis
Joint Authors
Nakamura, Akira
Takai, Toshiyuki
Endo, Shota
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
PIR-B, an inhibitory receptor expressed on murine B cells and myeloid cells, regulates humoral and cellular immune responses via its constitutive binding to the ligand, MHC class I molecules, on the same cells (cis) or on different cells (trans).
Although it has been speculated that PIR-B is important for maintaining peripheral tolerance, PIR-B single deficiency does not cause overt autoimmune diseases.
Recently, however, the combination of its deficiency with the Fas lpr mutation was found to result in augmented production of autoantibodies such as IgG rheumatoid factor and anti-DNA IgG, leading to glomerulonephritis in mice.
Although the precise molecular mechanism for the overall scenario is unclear, PIR-B was found to suppress TLR9-mediated production of naturally autoreactive antibodies by innate B cells or B-1 cells by inhibiting the activation of Bruton's tyrosine kinase.
Thus, PIR-B is an important regulator of innate immunity mediated by TLR9 in B-1 cells, which can otherwise provoke autoimmunity when overactivated.
American Psychological Association (APA)
Takai, Toshiyuki& Nakamura, Akira& Endo, Shota. 2010. Role of PIR-B in Autoimmune Glomerulonephritis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-459549
Modern Language Association (MLA)
Takai, Toshiyuki…[et al.]. Role of PIR-B in Autoimmune Glomerulonephritis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-459549
American Medical Association (AMA)
Takai, Toshiyuki& Nakamura, Akira& Endo, Shota. Role of PIR-B in Autoimmune Glomerulonephritis. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-459549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459549