Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps
Joint Authors
Paker, Nurcan
Gonen, Can
Babacan Abanonu, Gul
Colak, Yasar
Yesil, Atakan
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
To investigate the relationship between DR-70 serum levels and dysplastic colon polyps.
Materials and Methods.
A total of 130 patients with adenomatous polyps detected by colonoscopy and divided into two groups including low versus high grade polyp, along with 50 healthy blood donors were included in the study.
Blood samples from each participant were analyzed for serum CEA and DR-70 levels.
Results.
No statistically significant differences were observed between the two groups in terms of age or gender.
The median DR-70 level was 0.5 μg/mL in the healthy control group and 1.1 μg/mL in group 1b (i.e., the high grade polyp) (P<0.001).
DR-70 was higher in group 1b as compared to group 1a (P<0.001).
However, the median DR-70 values for the low grade polyp group (i.e., group 1a) and the control group were similar (P=0.067).
In order to determine independent predictors of high grade dysplasia, CEA, DR-70, polyp size, and age parameters were subjected to multiple logistical regression analyses via the Enter method; the model was statistically significant (P<0.001).
Conclusions.
DR-70, a marker used to measure FDP, which is generated by all major cancers, is a potential marker to identify patients with advanced adenomatous polyps, that is, precursors of colorectal cancer.
American Psychological Association (APA)
Yesil, Atakan& Babacan Abanonu, Gul& Colak, Yasar& Paker, Nurcan& Gonen, Can. 2013. Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459556
Modern Language Association (MLA)
Yesil, Atakan…[et al.]. Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps. Gastroenterology Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-459556
American Medical Association (AMA)
Yesil, Atakan& Babacan Abanonu, Gul& Colak, Yasar& Paker, Nurcan& Gonen, Can. Prognostic Significance of DR-70 Levels in Dysplastic Colorectal Polyps. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459556