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Basal Activation of Type I Interferons (Alpha2 and Beta) and 2′5′OAS Genes : Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis
Joint Authors
Bonjardim, Claudio Antônio
Guedes, Antônio Carlos Martins
Oliveira, Danilo Bretas de
Almeida, Gabriel Magno de Freitas
Santos, Flávia Patrícia Sena Teixeira
Ferreira, Paulo César Peregrino
Kroon, Erna Geessien
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Systemic sclerosis (SSc) is a complex autoimmune disease in which interferons (IFNs) may play an essential role.
We hypothesized that type I and III IFNs may be found in increased levels in patients and be responsible for SSc autoimmune status.
Methods.
Type I and III IFN and ISG basal expression profiles were measured by qPCR using RNA from PBMCs of patients and controls .
Results.
Type I IFNs are increased in SSc patients, while no induction of type III IFNs was detected.
This induction cannot be related to IRF7, since no upregulation of this gene was seen on patients.
Of the ISGs tested, 2′5′OAS levels were increased in patients, while 6–16 and MxA levels were not.
Conclusions.
While there is no indication of type III IFN induction, increased levels of type I IFNs may lead to abnormal regulation of ISGs that can be responsible for immune system alterations described for SSc.
American Psychological Association (APA)
Oliveira, Danilo Bretas de& Almeida, Gabriel Magno de Freitas& Guedes, Antônio Carlos Martins& Santos, Flávia Patrícia Sena Teixeira& Bonjardim, Claudio Antônio& Ferreira, Paulo César Peregrino…[et al.]. 2011. Basal Activation of Type I Interferons (Alpha2 and Beta) and 2′5′OAS Genes : Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-459567
Modern Language Association (MLA)
Oliveira, Danilo Bretas de…[et al.]. Basal Activation of Type I Interferons (Alpha2 and Beta) and 2′5′OAS Genes : Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis. International Journal of Rheumatology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-459567
American Medical Association (AMA)
Oliveira, Danilo Bretas de& Almeida, Gabriel Magno de Freitas& Guedes, Antônio Carlos Martins& Santos, Flávia Patrícia Sena Teixeira& Bonjardim, Claudio Antônio& Ferreira, Paulo César Peregrino…[et al.]. Basal Activation of Type I Interferons (Alpha2 and Beta) and 2′5′OAS Genes : Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-459567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459567