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The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias
Joint Authors
Source
Leukemia Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
The development of the genetic studies on acute myeloid leukemias (AMLs) has led to the identification of some recurrent genetic abnormalities.
Their discovery was of fundamental importance not only for a better understanding of the molecular pathogenesis of AMLs, but also for the identification of new therapeutic targets.
In this context, it is essential to identify AML-associated “driver” mutations, which have a causative role in leukemogenesis.
Evidences accumulated during the last years indicate that activating internal tandem duplication mutations in FLT3 (FLT3-ITD), detected in about 20% of AMLs, represents driver mutations and valid therapeutic targets in AMLs.
Furthermore, the screening of FLT3-ITD mutations has also considerably helped to improve the identification of more accurate prognostic criteria and of the therapeutic selection of patients.
American Psychological Association (APA)
Testa, Ugo& Pelosi, Elvira. 2013. The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias. Leukemia Research and Treatment،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-459588
Modern Language Association (MLA)
Testa, Ugo& Pelosi, Elvira. The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias. Leukemia Research and Treatment No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-459588
American Medical Association (AMA)
Testa, Ugo& Pelosi, Elvira. The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias. Leukemia Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-459588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459588