Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome

Abstract EN

The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases.

Psoriasis has been recently established to be a systemic disease centered on inflammation and involvement of cytokines of the Th1 pathway.

There is an increased prevalence of metabolic syndrome in patients with psoriasis.

Metabolic syndrome also involves a proinflammatory state.

This paper proposes the idea of the potential use of oral vitamin D to treat psoriasis and metabolic syndrome concurrently.

We propose there is merit in more clinical trials investigating the use of vitamin D to treat both psoriasis and metabolic syndrome through its anti-inflammatory effects.

On application to psoriasis management and prognosis, the goal is to decrease the risk for cardiovascular disease and decrease disease morbidity and mortality.