Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma
Joint Authors
Wang, Yongxing
Lozano, Guillermina
Lin, Patrick P.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The origin of Ewing's sarcoma is a subject of much debate.
Once thought to be derived from primitive neuroectodermal cells, many now believe it to arise from a mesenchymal stem cell (MSC).
Expression of the EWS-FLI1 fusion gene in MSCs changes cell morphology to resemble Ewing's sarcoma and induces expression of neuroectodermal markers.
In murine cells, transformation to sarcomas can occur.
In knockdown experiments, Ewing's sarcoma cells develop characteristics of MSCs and the ability to differentiate into mesodermal lineages.
However, it cannot be concluded that MSCs are the cell of origin.
The concept of an MSC still needs to be rigorously defined, and there may be different subpopulations of mesenchymal pluripotential cells.
Furthermore, EWS-FLI1 by itself does not transform human cells, and cooperating mutations appear to be necessary.
Therefore, while it is possible that Ewing's sarcoma may originate from a primitive mesenchymal cell, the idea needs to be refined further.
American Psychological Association (APA)
Lin, Patrick P.& Wang, Yongxing& Lozano, Guillermina. 2010. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma. Sarcoma،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-459647
Modern Language Association (MLA)
Lin, Patrick P.…[et al.]. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma. Sarcoma No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-459647
American Medical Association (AMA)
Lin, Patrick P.& Wang, Yongxing& Lozano, Guillermina. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma. Sarcoma. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-459647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459647