Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland
Joint Authors
Helzlsouer, Kathy J.
Strickland, Paul
Kalesan, Bindu
Hoffman, Sandra C.
Gallicchio, L.
Huang, Han-Yao
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-12-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The primary aim of this study was to examine prospectively the associations between 5 peroxisome proliferator-activated receptor (PPAR) single nucleotide polymorphisms (SNPs) and cardiovascular morbidity and mortality in a community-based cohort study in Washington County, Maryland.
Data were analyzed from 9,364 Caucasian men and women participating in CLUE-II.
Genotyping on 5 PPAR polymorphisms was conducted using peripheral DNA samples collected in 1989.
The followup period was from 1989 to 2003.
The results showed that there were no statistically significant associations between the PPAR SNPs and cardiovascular deaths or events.
In contrast, statistically significant age-adjusted associations were observed for PPARG rs4684847 with both baseline body mass and blood pressure, and for PPARG rs709158, PPARG rs1175543, and PPARD rs2016520 with baseline cholesterol levels.
Future studies should be conducted to confirm these findings and to explore the associations in populations with greater racial and ethnic diversity.
American Psychological Association (APA)
Gallicchio, L.& Kalesan, Bindu& Huang, Han-Yao& Strickland, Paul& Hoffman, Sandra C.& Helzlsouer, Kathy J.. 2007. Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland. PPAR Research،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-459661
Modern Language Association (MLA)
Gallicchio, L.…[et al.]. Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland. PPAR Research No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-459661
American Medical Association (AMA)
Gallicchio, L.& Kalesan, Bindu& Huang, Han-Yao& Strickland, Paul& Hoffman, Sandra C.& Helzlsouer, Kathy J.. Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-459661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459661