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Cerebral Melanoma Metastases : A Critical Review on Diagnostic Methods and Therapeutic Options
Joint Authors
Ramina, Ricardo
Mattei, Tobias Alecio
Goulart, Carlos R.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Malignant melanoma represents the third most common cause for cerebral metastases after breast and lung cancer.
Central nervous system (CNS) metastases occur in 10 to 40% of patients with melanoma.
Most of the symptoms of CNS melanoma metastases are unspecific and depend on localization of the lesion.
All patients with new neurological signs and a previous primary melanoma lesion must be investigated.
Although primary diagnosis may rely on computed tomography scan, magnetic resonance images are usually used in order to study more precisely the characteristics of the lesions in and to embase the surgical plan.
Other possible complementary exams are: positron emission tomography, iofetamine cintilography, immunohistochemistry of liquor, monoclonal antibody immunocytology, optical coherence tomography, and transcriptase-polymerase chain reaction.
Treatment procedures are indicated based on patient clinical status, presence of unique or multiple lesions, and family agreement.
Often surgery, radiosurgery, whole brain radiotherapy, and chemotherapy are combined in order to obtain longer remissions and optimal symptom relieve.
Corticoids may be also useful in those cases that present with remarkable peritumoral edema and important mass effect.
Despite of the advance in therapeutic options, prognosis for patients with melanoma brain metastases remains poor with a median survival time of six months after diagnosis.
American Psychological Association (APA)
Goulart, Carlos R.& Mattei, Tobias Alecio& Ramina, Ricardo. 2011. Cerebral Melanoma Metastases : A Critical Review on Diagnostic Methods and Therapeutic Options. ISRN Surgery،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-459681
Modern Language Association (MLA)
Goulart, Carlos R.…[et al.]. Cerebral Melanoma Metastases : A Critical Review on Diagnostic Methods and Therapeutic Options. ISRN Surgery No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-459681
American Medical Association (AMA)
Goulart, Carlos R.& Mattei, Tobias Alecio& Ramina, Ricardo. Cerebral Melanoma Metastases : A Critical Review on Diagnostic Methods and Therapeutic Options. ISRN Surgery. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-459681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459681