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Regulation of Ribosomal RNA Production by RNA Polymerase I : Does Elongation Come First?
Joint Authors
Perez-Fernandez, Jorge
Albert, Benjamin
Gadal, Olivier
Léger-Silvestre, Isabelle
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ribosomal RNA (rRNA) production represents the most active transcription in the cell.
Synthesis of the large rRNA precursors (35–47S) can be achieved by up to 150 RNA polymerase I (Pol I) enzymes simultaneously transcribing each rRNA gene.
In this paper, we present recent advances made in understanding the regulatory mechanisms that control elongation.
Built-in Pol I elongation factors, such as Rpa34/Rpa49 in budding yeast and PAF53/CAST in humans, are instrumental to the extremely high rate of rRNA production per gene.
rRNA elongation mechanisms are intrinsically linked to chromatin structure and to the higher-order organization of the rRNA genes (rDNA).
Factors such as Hmo1 in yeast and UBF1 in humans are key players in rDNA chromatin structure in vivo.
Finally, elongation factors known to regulate messengers RNA production by RNA polymerase II are also involved in rRNA production and work cooperatively with Rpa49 in vivo.
American Psychological Association (APA)
Albert, Benjamin& Perez-Fernandez, Jorge& Léger-Silvestre, Isabelle& Gadal, Olivier. 2012. Regulation of Ribosomal RNA Production by RNA Polymerase I : Does Elongation Come First?. Genetics Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-459686
Modern Language Association (MLA)
Albert, Benjamin…[et al.]. Regulation of Ribosomal RNA Production by RNA Polymerase I : Does Elongation Come First?. Genetics Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-459686
American Medical Association (AMA)
Albert, Benjamin& Perez-Fernandez, Jorge& Léger-Silvestre, Isabelle& Gadal, Olivier. Regulation of Ribosomal RNA Production by RNA Polymerase I : Does Elongation Come First?. Genetics Research International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-459686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459686