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AUTO-MUTE 2.0 : A Portable Framework with Enhanced Capabilities for Predicting Protein Functional Consequences upon Mutation
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The AUTO-MUTE 2.0 stand-alone software package includes a collection of programs for predicting functional changes to proteins upon single residue substitutions, developed by combining structure-based features with trained statistical learning models.
Three of the predictors evaluate changes to protein stability upon mutation, each complementing a distinct experimental approach.
Two additional classifiers are available, one for predicting activity changes due to residue replacements and the other for determining the disease potential of mutations associated with nonsynonymous single nucleotide polymorphisms (nsSNPs) in human proteins.
These five command-line driven tools, as well as all the supporting programs, complement those that run our AUTO-MUTE web-based server.
Nevertheless, all the codes have been rewritten and substantially altered for the new portable software, and they incorporate several new features based on user feedback.
Included among these upgrades is the ability to perform three highly requested tasks: to run “big data” batch jobs; to generate predictions using modified protein data bank (PDB) structures, and unpublished personal models prepared using standard PDB file formatting; and to utilize NMR structure files that contain multiple models.
American Psychological Association (APA)
Masso, Majid& Vaisman, Iosif I.. 2014. AUTO-MUTE 2.0 : A Portable Framework with Enhanced Capabilities for Predicting Protein Functional Consequences upon Mutation. Advances in Bioinformatics،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-459733
Modern Language Association (MLA)
Masso, Majid& Vaisman, Iosif I.. AUTO-MUTE 2.0 : A Portable Framework with Enhanced Capabilities for Predicting Protein Functional Consequences upon Mutation. Advances in Bioinformatics No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-459733
American Medical Association (AMA)
Masso, Majid& Vaisman, Iosif I.. AUTO-MUTE 2.0 : A Portable Framework with Enhanced Capabilities for Predicting Protein Functional Consequences upon Mutation. Advances in Bioinformatics. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-459733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459733