![](/images/graphics-bg.png)
Vitexicarpin Acts as a Novel Angiogenesis Inhibitor and Its Target Network
Joint Authors
Zhang, Bo
Zhao, Shiwen
Liu, Liyang
Li, Shao
Liu, Lu
Wang, Xu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Vitexicarpin (VIT) isolated from the fruits of Vitex rotundifolia has shown antitumor, anti-inflammatory, and immunoregulatory properties.
This work is designed to evaluate the antiangiogenic effects of VIT and address the underlying action mechanism of VIT by a network pharmacology approach.
The results validated that VIT can act as a novel angiogenesis inhibitor.
Firstly, VIT can exert good antiangiogenic effects by inhibiting vascular-endothelial-growth-factor- (VEGF-) induced endothelial cell proliferation, migration, and capillary-like tube formation on matrigel in a dose-dependent manner.
Secondly, VIT was also shown to have an antiangiogenic mechanism through inhibition of cell cycle progression and induction of apoptosis.
Thirdly, VIT inhibited chorioallantoic membrane angiogenesis as well as tumor angiogenesis in an allograft mouse tumor model.
We further addressed VIT’s molecular mechanism of antiangiogenic actions using one of our network pharmacology methods named drugCIPHER.
Then, we tested some key molecules in the VEGF pathway targeted by VIT and verified the inhibition effects of VIT on AKT and SRC phosphorylation.
Taken together, this work not only identifies VIT as a novel potent angiogenesis inhibitor, but also demonstrates that network pharmacology methods can be an effective and promising approach to make discovery and understand the action mechanism of herbal ingredients.
American Psychological Association (APA)
Zhang, Bo& Liu, Lu& Zhao, Shiwen& Wang, Xu& Liu, Liyang& Li, Shao. 2013. Vitexicarpin Acts as a Novel Angiogenesis Inhibitor and Its Target Network. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-459735
Modern Language Association (MLA)
Zhang, Bo…[et al.]. Vitexicarpin Acts as a Novel Angiogenesis Inhibitor and Its Target Network. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-459735
American Medical Association (AMA)
Zhang, Bo& Liu, Lu& Zhao, Shiwen& Wang, Xu& Liu, Liyang& Li, Shao. Vitexicarpin Acts as a Novel Angiogenesis Inhibitor and Its Target Network. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-459735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459735