Synthesis of Clinical-Grade [18F]-Fluoroestradiol as a Surrogate PET Biomarker for the Evaluation of Estrogen Receptor-Targeting Therapeutic Drug
Joint Authors
Dixit, Manish
Shi, Jianfeng
Wei, Ling
Afari, George
Bhattacharyya, Sibaprasad
Source
International Journal of Molecular Imaging
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
16α-[18F]-fluoroestradiol ([18F]FES), a steroid-based positron emission tomography (PET) tracer, has emerged as a dependable tracer for the evaluation and management of estrogen receptor-positive (ER+) breast cancer patients.
We have developed a fully automatic, one-pot procedure for the synthesis of [18F]FES using the Eckert & Ziegler (E & Z) radiomodular system.
After [18F]fluorination, the intermediate was hydrolyzed with 2.0 M HCl twice and neutralized with sodium bicarbonate.
After high-performance liquid chromatography (HPLC) purification, the decay-corrected radiochemical yield and purity of [18F]FES were 40 ± 5.0% (n=12) and >97%, respectively.
The product was stable up to 10 h.
Total synthesis time including HPLC purification was 80 min.
This new, fully automated rapid synthetic procedure provided high and reproducible yields of [18F]FES.
Quality control (QC) tests showed that the [18F]FES produced by this method met all specifications for human injection.
American Psychological Association (APA)
Dixit, Manish& Shi, Jianfeng& Wei, Ling& Afari, George& Bhattacharyya, Sibaprasad. 2013. Synthesis of Clinical-Grade [18F]-Fluoroestradiol as a Surrogate PET Biomarker for the Evaluation of Estrogen Receptor-Targeting Therapeutic Drug. International Journal of Molecular Imaging،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-459751
Modern Language Association (MLA)
Dixit, Manish…[et al.]. Synthesis of Clinical-Grade [18F]-Fluoroestradiol as a Surrogate PET Biomarker for the Evaluation of Estrogen Receptor-Targeting Therapeutic Drug. International Journal of Molecular Imaging No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-459751
American Medical Association (AMA)
Dixit, Manish& Shi, Jianfeng& Wei, Ling& Afari, George& Bhattacharyya, Sibaprasad. Synthesis of Clinical-Grade [18F]-Fluoroestradiol as a Surrogate PET Biomarker for the Evaluation of Estrogen Receptor-Targeting Therapeutic Drug. International Journal of Molecular Imaging. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-459751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459751