An Integrative Network Biology Approach to Evaluate the Role of Endoplasmic Reticulum Stress Response in Obese Type 2 Diabetes
Joint Authors
Mammen Oommen, Anup
Jagannath, M. R.
Narayanan, Usha
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Extracellular/intracellular stimuli can influence eukaryotic cell function through organelles that regulate critical signaling pathways.
The endoplasmic reticulum (ER), for example, impacts cellular processes including protein synthesis, folding and secretion; amino acid transport; apoptosis; cell proliferation; lipid synthesis across major cell types in response to stimuli such as accumulation of misfolded proteins and glucose deprivation.
Dysregulated signaling pathways underlying the ER-mediated processes mentioned above have been linked to disease conditions such as diabetes, obesity, and Alzheimer's disease.
Our current understanding, however, lacks a detailed network view that integrates organelle-mediated pathway dysregulation with cellular processes and disease pathogenesis.
In this report, we introduce an integrative network biology approach that combines ER-stress response pathways with basic cellular processes using data from peer-reviewed literature.
As an example, we apply our systems biology approach to study the role of ER stress in pancreatic β cells under obese diabetic conditions, generate testable hypotheses, and provide novel insights into β-cell pathogenesis.
American Psychological Association (APA)
Mammen Oommen, Anup& Narayanan, Usha& Jagannath, M. R.. 2012. An Integrative Network Biology Approach to Evaluate the Role of Endoplasmic Reticulum Stress Response in Obese Type 2 Diabetes. ISRN Cell Biology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-459756
Modern Language Association (MLA)
Mammen Oommen, Anup…[et al.]. An Integrative Network Biology Approach to Evaluate the Role of Endoplasmic Reticulum Stress Response in Obese Type 2 Diabetes. ISRN Cell Biology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-459756
American Medical Association (AMA)
Mammen Oommen, Anup& Narayanan, Usha& Jagannath, M. R.. An Integrative Network Biology Approach to Evaluate the Role of Endoplasmic Reticulum Stress Response in Obese Type 2 Diabetes. ISRN Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-459756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459756