From Transcriptome to Noncoding RNAs : Implications in ALS Mechanism
Joint Authors
Pansarasa, Orietta
Cereda, Cristina
Milani, Pamela
Gagliardi, Stella
Sardone, Valentina
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In the last years, numerous studies have focused on understanding the metabolism of RNA and its implication in disease processes but abnormal RNA metabolism is still unknown.
RNA plays a central role in translating genetic information into proteins and in many other catalytic and regulatory tasks.
Recent advances in the study of RNA metabolism revealed complex pathways for the generation and maintenance of functional RNA in amyotrophic lateral sclerosis (ALS).
Interestingly, perturbations in RNA processing have been described in ALS at various levels such as gene transcription, mRNA stabilization, transport, and translational regulations.
In this paper, we will discuss the alteration of RNA profile in ALS disease, starting from transcription, the first step leading to gene expression, through the posttranscriptional regulation, including RNA/DNA binding proteins and aberrant exon splicing to protein noncoding RNAs, as lncRNA and microRNA.
American Psychological Association (APA)
Gagliardi, Stella& Milani, Pamela& Sardone, Valentina& Pansarasa, Orietta& Cereda, Cristina. 2012. From Transcriptome to Noncoding RNAs : Implications in ALS Mechanism. Neurology Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459763
Modern Language Association (MLA)
Gagliardi, Stella…[et al.]. From Transcriptome to Noncoding RNAs : Implications in ALS Mechanism. Neurology Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-459763
American Medical Association (AMA)
Gagliardi, Stella& Milani, Pamela& Sardone, Valentina& Pansarasa, Orietta& Cereda, Cristina. From Transcriptome to Noncoding RNAs : Implications in ALS Mechanism. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459763