Molecular Modeling Studies of Piperidine Derivatives as New Acetylcholinesterase Inhibitors against Neurodegenerative Diseases
Joint Authors
Gonçalves, Mateus Aquino
Ramalho, Teodorico C.
da Cunha, Elaine F. F.
Costa França, Tanos Celmar
Santos-Garcia, Letícia
de Souza, Felipe R.
Resende, José E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Neurodegenerative disorders are related to the progressive loss of structure or function and, eventually, death of neurons.
These processes are responsible for diseases like Parkinson’s, Alzheimer’s, and Huntington’s, and the main molecular target for the drug design against these illnesses today is the enzyme acetylcholinesterase (AChE).
Following this line, in the present work, we applied docking techniques to study some piperidine derivative inhibitors of AChE and further propose structures of six new AChE inhibitors as potential new drugs against neurodegenerative disorders.
The best inhibitor proposed was submitted to additional molecular dynamics simulations steps.
American Psychological Association (APA)
da Cunha, Elaine F. F.& Resende, José E.& Costa França, Tanos Celmar& Gonçalves, Mateus Aquino& de Souza, Felipe R.& Santos-Garcia, Letícia…[et al.]. 2013. Molecular Modeling Studies of Piperidine Derivatives as New Acetylcholinesterase Inhibitors against Neurodegenerative Diseases. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459767
Modern Language Association (MLA)
da Cunha, Elaine F. F.…[et al.]. Molecular Modeling Studies of Piperidine Derivatives as New Acetylcholinesterase Inhibitors against Neurodegenerative Diseases. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-459767
American Medical Association (AMA)
da Cunha, Elaine F. F.& Resende, José E.& Costa França, Tanos Celmar& Gonçalves, Mateus Aquino& de Souza, Felipe R.& Santos-Garcia, Letícia…[et al.]. Molecular Modeling Studies of Piperidine Derivatives as New Acetylcholinesterase Inhibitors against Neurodegenerative Diseases. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459767