Integrated Analysis of Gene Network in Childhood Leukemia from Microarray and Pathway Databases
Joint Authors
Kulasiri, Don
Samarasinghe, Sandhya
Chaiboonchoe, Amphun
Salehi-Ashtiani, Kourosh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glucocorticoids (GCs) have been used as therapeutic agents for children with acute lymphoblastic leukaemia (ALL) for over 50 years.
However, much remains to be understood about the molecular mechanism of GCs actions in ALL subtypes.
In this study, we delineate differential responses of ALL subtypes, B- and T-ALL, to GCs treatment at systems level by identifying the differences among biological processes, molecular pathways, and interaction networks that emerge from the action of GCs through the use of a selected number of available bioinformatics methods and tools.
We provide biological insight into GC-regulated genes, their related functions, and their networks specific to the ALL subtypes.
We show that differentially expressed GC-regulated genes participate in distinct underlying biological processes affected by GCs in B-ALL and T-ALL with little to no overlap.
These findings provide the opportunity towards identifying new therapeutic targets.
American Psychological Association (APA)
Chaiboonchoe, Amphun& Samarasinghe, Sandhya& Kulasiri, Don& Salehi-Ashtiani, Kourosh. 2014. Integrated Analysis of Gene Network in Childhood Leukemia from Microarray and Pathway Databases. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-459768
Modern Language Association (MLA)
Chaiboonchoe, Amphun…[et al.]. Integrated Analysis of Gene Network in Childhood Leukemia from Microarray and Pathway Databases. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-459768
American Medical Association (AMA)
Chaiboonchoe, Amphun& Samarasinghe, Sandhya& Kulasiri, Don& Salehi-Ashtiani, Kourosh. Integrated Analysis of Gene Network in Childhood Leukemia from Microarray and Pathway Databases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-459768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459768