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What Can Domesticated Genes Tell Us about the Intron Gain in Mammals?
Joint Authors
Source
International Journal of Evolutionary Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Domesticated genes, originating from retroelements or from DNA-transposons, constitute an ideal system for testing the hypothesis on the absence of intron gain in mammals.
Since single-copy domesticated genes originated from the intronless multicopy transposable elements, the ancestral intron state for domesticated genes is zero.
A phylogenomic approach has been used to analyse all domesticated genes in mammals and chordates that originated from the coding parts of transposable elements.
A significant amount of intron gain was found only in domesticated genes of placental mammals, where more than 70 cases were identified.
De novo gained introns show clear positional bias, since they are distributed mainly in 5′ UTR and coding regions, while 3′ UTR introns are very rare.
In the coding regions of some domesticated genes up to 8 de novo gained introns have been found.
Surprisingly, the majority of intron gains have occurred in the ancestor of placental mammals.
Domesticated genes could constitute an excellent system on which to analyse the mechanisms of intron gain.
This paper summarizes the current understanding of intron gain in mammals.
American Psychological Association (APA)
Kordiš, Dušan& Kokošar, Janez. 2012. What Can Domesticated Genes Tell Us about the Intron Gain in Mammals?. International Journal of Evolutionary Biology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459789
Modern Language Association (MLA)
Kordiš, Dušan& Kokošar, Janez. What Can Domesticated Genes Tell Us about the Intron Gain in Mammals?. International Journal of Evolutionary Biology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-459789
American Medical Association (AMA)
Kordiš, Dušan& Kokošar, Janez. What Can Domesticated Genes Tell Us about the Intron Gain in Mammals?. International Journal of Evolutionary Biology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459789