Maintenance or Emergence of Chronic Phase Secondary Cytotoxic T Lymphocyte Responses after Loss of Acute Phase Immunodominant Responses Does Not Protect SIV-Infected Rhesus Macaques from Disease Progression

Joint Authors

Parodi, Laura M.
Hodara, Vida L.
Keckler, M. Shannon
Giavedoni, Luis D.

Source

Journal of Biomedicine and Biotechnology

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-05-25

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

The simian immunodeficiency virus- (SIV-) infected rhesus macaque is the preferred animal model for vaccine development, but the correlates of protection in this model are not completely understood.

In this paper, we document the cytotoxic T lymphocyte (CTL) response to SIV and its effects on viral evolution in an effort to identify events associated with disease progression regardless of MHC allele expression.

We observed the evolution of epitopes targeted by CTLs in a group of macaques that included long-term nonprogressing (LTNP), slowly progressing (SP), normally progressing (NP), and rapidly progressing (RP) animals.

Collectively, our data (1) identify novel CTL epitopes from an SP animal that are not restricted by known protective alleles, (2) illustrate that, in this small study, RP and NP animals accrue more mutations in CTL epitopes than in SP or LTNP macaques, and (3) demonstrate that the loss of CTL responses to immunodominant epitopes is associated with viral replication increases, which are not controlled by secondary CTL responses.

These findings provide further evidence for the critical role of the primary cell-mediated immune responses in the control of retroviral infections.

American Psychological Association (APA)

Keckler, M. Shannon& Hodara, Vida L.& Parodi, Laura M.& Giavedoni, Luis D.. 2010. Maintenance or Emergence of Chronic Phase Secondary Cytotoxic T Lymphocyte Responses after Loss of Acute Phase Immunodominant Responses Does Not Protect SIV-Infected Rhesus Macaques from Disease Progression. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-459822

Modern Language Association (MLA)

Keckler, M. Shannon…[et al.]. Maintenance or Emergence of Chronic Phase Secondary Cytotoxic T Lymphocyte Responses after Loss of Acute Phase Immunodominant Responses Does Not Protect SIV-Infected Rhesus Macaques from Disease Progression. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-459822

American Medical Association (AMA)

Keckler, M. Shannon& Hodara, Vida L.& Parodi, Laura M.& Giavedoni, Luis D.. Maintenance or Emergence of Chronic Phase Secondary Cytotoxic T Lymphocyte Responses after Loss of Acute Phase Immunodominant Responses Does Not Protect SIV-Infected Rhesus Macaques from Disease Progression. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-459822

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-459822