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Eugenia uniflora L. Essential Oil as a Potential Anti-Leishmania Agent : Effects on Leishmania amazonensis and Possible Mechanisms of Action
Joint Authors
Rodrigues, Klinger Antonio da Franca
Carneiro, Sabrina Maria Portela
Carvalho, Fernando Aécio de Amorim
Moraes, Denise Fernandes Coutinho
Dias, Clarice Noleto
Andrade, Eloisa Helena de Aguiar
Oliveira, Jamylla Mirck Guerra de
Amorim, Layane Valéria
Maia, Jose Guilherme Soares
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Eugenia uniflora L.
is a member of the Myrtaceae family and is commonly known as Brazilian cherry tree.
In this study, we evaluated the chemical composition of Eugenia uniflora L.
essential oil (EuEO) by using gas chromatography-mass spectrometry (GC-MS) and assessed its anti-Leishmania activity.
We also explored the potential mechanisms of action and cytotoxicity of EuEO.
Thirty-two compounds were identified, which constituted 92.65% of the total oil composition.
The most abundant components were sesquiterpenes (91.92%), with curzerene (47.3%), γ-elemene (14.25%), and trans-β-elemenone (10.4%) being the major constituents.
The bioactivity shown by EuEO against promastigotes (IC50, 3.04 μg·mL−1) and amastigotes (IC50, 1.92 μg·mL−1) suggested significant anti-Leishmania activity.
In the cytotoxicity determination, EuEO was 20 times more toxic to amastigotes than to macrophages.
Hemolytic activity was 63.22% at the highest concentration tested (400 μg·mL−1); however, there appeared to be no toxicity at 50 μg·mL−1.
While the data show that EuEO activity is not mediated by nitric oxide production, they do suggest that macrophage activation may be involved in EuEO anti-Leishmania activity, as evidenced by increases in both the phagocytic capacity and the lysosomal activity.
More studies are needed to determine in vivo activity as well as additional mechanisms of the anti-Leishmania activity.
American Psychological Association (APA)
Rodrigues, Klinger Antonio da Franca& Amorim, Layane Valéria& Oliveira, Jamylla Mirck Guerra de& Dias, Clarice Noleto& Moraes, Denise Fernandes Coutinho& Andrade, Eloisa Helena de Aguiar…[et al.]. 2013. Eugenia uniflora L. Essential Oil as a Potential Anti-Leishmania Agent : Effects on Leishmania amazonensis and Possible Mechanisms of Action. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-459860
Modern Language Association (MLA)
Rodrigues, Klinger Antonio da Franca…[et al.]. Eugenia uniflora L. Essential Oil as a Potential Anti-Leishmania Agent : Effects on Leishmania amazonensis and Possible Mechanisms of Action. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-459860
American Medical Association (AMA)
Rodrigues, Klinger Antonio da Franca& Amorim, Layane Valéria& Oliveira, Jamylla Mirck Guerra de& Dias, Clarice Noleto& Moraes, Denise Fernandes Coutinho& Andrade, Eloisa Helena de Aguiar…[et al.]. Eugenia uniflora L. Essential Oil as a Potential Anti-Leishmania Agent : Effects on Leishmania amazonensis and Possible Mechanisms of Action. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-459860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459860