Ga68-NOTA-CHSg and Tc99m-CHSg Labeled Microspheres for Lung Perfusion and Liver Radiomicrospheres Therapy Planning
Joint Authors
Amor-Coarasa, Alejandro
Leichner, Jared
McGoron, Anthony J.
Gulec, Seza
Milera, Andrew
Carvajal, Denny
Source
International Journal of Molecular Imaging
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fast biodegradable (12 h < half-life < 48 h) radioactive labeled microspheres are needed for PET and SPECT lung perfusion and radiomicrosphere therapy planning.
An emulsion method was used to create 30.1 ±4.8 μm size range microspheres with biodegradable Chitosan glycol (CHSg).
Microspheres were characterized and labeled with Tc99m or Ga68 as an alternative to MAA in perfusion PET and SPECT studies.
Surface decoration of CHSg microspheres with p-SCN-Bn-NOTA was performed to increase Ga68 in vivo stability.
Tc99m was labeled directly to the CHSg microspheres.
Labeling yield and in vitro radiochemical stability were evaluated.
In vitro CHSg microsphere degradation half-life was ~24 hours in porcine blood.
Labeled microspheres were injected into Sprague Dawley rats and biodistribution was determined after 2 and 4 hours.
Both Tc99m-CHSg and Ga68-NOTA-CHSg were quickly allocated in the lungs after injection.
Tc99m-CHSg showed 91.6 ± 6.5% and 83.2 ± 4.1% of the decay corrected injected activity remaining in the lungs after 2 and 4 hours, respectively.
For the obtained Ga68-NOTA-CHSg microspheres, lung allocation was very high with 98.9 ± 0.2% and 95.6 ± 0.9% after 2 and 4 hours, respectively.
The addition of p-SCN-Bn-NOTA acts as a radioprotectant eliminating the released Ga68 activity from the lungs to the bladder protecting the other organs.
American Psychological Association (APA)
Amor-Coarasa, Alejandro& Milera, Andrew& Carvajal, Denny& Gulec, Seza& Leichner, Jared& McGoron, Anthony J.. 2013. Ga68-NOTA-CHSg and Tc99m-CHSg Labeled Microspheres for Lung Perfusion and Liver Radiomicrospheres Therapy Planning. International Journal of Molecular Imaging،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-459872
Modern Language Association (MLA)
Amor-Coarasa, Alejandro…[et al.]. Ga68-NOTA-CHSg and Tc99m-CHSg Labeled Microspheres for Lung Perfusion and Liver Radiomicrospheres Therapy Planning. International Journal of Molecular Imaging No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-459872
American Medical Association (AMA)
Amor-Coarasa, Alejandro& Milera, Andrew& Carvajal, Denny& Gulec, Seza& Leichner, Jared& McGoron, Anthony J.. Ga68-NOTA-CHSg and Tc99m-CHSg Labeled Microspheres for Lung Perfusion and Liver Radiomicrospheres Therapy Planning. International Journal of Molecular Imaging. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-459872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459872