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Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine
Joint Authors
Thomson, Alan Bryan Robert
Schnabl, Kareena Leanne
Mazurak, Vera Christine
Clandinin, Michael Thomas
Miklavcic, John Janez
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gangliosides are integral to the structure and function of cell membranes.
Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division, differentiation, and signaling.
Accelerated catabolism of ganglioside in intestinal disease results in increased proinflammatory signaling.
Restoring proper structure and function to the diseased intestine can resolve inflammation, increase resistance to infection, and improve gut integrity to induce remission of conditions like necrotizing enterocolitis (NEC) and Crohn's disease (CD).
Maintaining inactive state of disease may be achieved by reducing the rate that gangliosides are degraded or by increasing intake of dietary ganglioside.
Collectively, the studies outlined in this paper indicate that the amount of gangliosides GM3 and GD3 in intestinal mucosa is decreased with inflammation, low level of GM3 is associated with higher production of proinflammatory signals, and ganglioside content of intestinal mucosa can be increased by dietary ganglioside.
American Psychological Association (APA)
Miklavcic, John Janez& Schnabl, Kareena Leanne& Mazurak, Vera Christine& Thomson, Alan Bryan Robert& Clandinin, Michael Thomas. 2012. Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-459885
Modern Language Association (MLA)
Miklavcic, John Janez…[et al.]. Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-459885
American Medical Association (AMA)
Miklavcic, John Janez& Schnabl, Kareena Leanne& Mazurak, Vera Christine& Thomson, Alan Bryan Robert& Clandinin, Michael Thomas. Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-459885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459885