Astragalus Polysaccharide Suppresses the Expression of Adhesion Molecules through the Regulation of the p38 MAPK Signaling Pathway in Human Cardiac Microvascular Endothelial Cells after Ischemia-Reperfusion Injury
Joint Authors
Ai-Ming, Wu
Li-Xin, Chen
Bing, Xu
Zhi-Yao, Wang
Yan-Wei, Xing
Hai-Yan, Zhu
Yong-Hong, Gao
Li-Xia, Lou
Bei, Liu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Astragalus polysaccharide is a major component of radix astragali, a vital qi-reinforcing herb medicine with favorable immune-regulating effects.
In a previous animal experiment, we demonstrated that astragalus polysaccharide effectively alleviates ischemia-reperfusion injury (IRI) of cardiac muscle through the regulation of the inflammatory reactions.
However, the relationship between this herb and the cohesion molecules on the cell surface remains controversial.
In this study, human cardiac microvascular endothelial cells (HCMECs) were used to validate the protective effects of astragalus under an IRI scheme simulated through hypoxia/reoxygenation in vitro.
The results indicated that astragalus polysaccharide inhibited the cohesion between HCMECs and polymorphonuclear leukocyte (PMN) during IRI through the downregulation of p38 MAPK signaling and the reduction of cohesive molecule expression in HCMECs.
American Psychological Association (APA)
Hai-Yan, Zhu& Yong-Hong, Gao& Zhi-Yao, Wang& Bing, Xu& Ai-Ming, Wu& Yan-Wei, Xing…[et al.]. 2013. Astragalus Polysaccharide Suppresses the Expression of Adhesion Molecules through the Regulation of the p38 MAPK Signaling Pathway in Human Cardiac Microvascular Endothelial Cells after Ischemia-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-459907
Modern Language Association (MLA)
Hai-Yan, Zhu…[et al.]. Astragalus Polysaccharide Suppresses the Expression of Adhesion Molecules through the Regulation of the p38 MAPK Signaling Pathway in Human Cardiac Microvascular Endothelial Cells after Ischemia-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-459907
American Medical Association (AMA)
Hai-Yan, Zhu& Yong-Hong, Gao& Zhi-Yao, Wang& Bing, Xu& Ai-Ming, Wu& Yan-Wei, Xing…[et al.]. Astragalus Polysaccharide Suppresses the Expression of Adhesion Molecules through the Regulation of the p38 MAPK Signaling Pathway in Human Cardiac Microvascular Endothelial Cells after Ischemia-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-459907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459907