Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer's Disease Treatment
Joint Authors
Martinez, Ana
Perez, Daniel I.
Gil, Carmen
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glycogen synthase kinase 3 (GSK-3), a proline/serine protein kinase ubiquitously expressed and involved in many cellular signaling pathways, plays a key role in the pathogenesis of Alzheimer's disease (AD) being probably the link between β-amyloid and tau pathology.
A great effort has recently been done in the discovery and development of different new molecules, of synthetic and natural origin, able to inhibit this enzyme, and several kinetics mechanisms of binding have been described.
The small molecule called tideglusib belonging to the thiadiazolidindione family is currently on phase IIb clinical trials for AD.
The potential risks and benefits of this new kind of disease modifying drugs for the future therapy of AD are discussed in this paper.
American Psychological Association (APA)
Martinez, Ana& Gil, Carmen& Perez, Daniel I.. 2011. Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer's Disease Treatment. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-459908
Modern Language Association (MLA)
Martinez, Ana…[et al.]. Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer's Disease Treatment. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-459908
American Medical Association (AMA)
Martinez, Ana& Gil, Carmen& Perez, Daniel I.. Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer's Disease Treatment. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-459908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459908