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Vitamin D Deficiency Is Not Associated with Changes in Retinal Geometric Parameters in Young People with Type 1 Diabetes
Joint Authors
Poon, Myra
Sasongko, Muhammad Bayu
Donaghue, Kim C.
Cusumano, Janine
Wong, Tien Yin
Kaur, Harleen
Craig, Maria E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Changes in retinal geometric parameters predict risk and progression of diabetic retinopathy (DR).
We have shown that vitamin D deficiency (VDD) is associated with DR.
We hypothesized that VDD mediates changes in retinal geometric parameters.
Retinal vascular geometric parameters were assessed using a semiautomated computer program in photographs from young people with type 1 diabetes (T1D) (n=481) and summarized as central retinal arteriolar and venular equivalents (CRAE, CRVE), fractal dimension, length-diameter ratio, branching angle and curvature tortuosity.
Parameters were compared between those with and without DR and VDD (25-hydroxyvitamin D concentration ≤ 50 nmol/L).
Retinal vascular geometric parameters were also compared across quartiles of vitamin D levels.
Median CRVE was higher in patients with DR compared with those without (median (IQR) CRVE 247.3 μm (31.3) versus 238.8 μm (23.5), P=0.01).
Fractal dimension was marginally greater in patients without VDD (1.49 (0.06) versus 1.47 (0.07) P=0.03).
There was no difference in CRAE, CRVE, length-diameter ratio, branching angle, and curvature tortuosity between those with and without VDD and across quartiles of 25OHD.
In conclusion, DR is associated with higher CRVE in young people with T1D; however, VDD is not associated with changes in retinal vascular geometric measures, suggesting an earlier role in the time course of DR pathogenesis.
American Psychological Association (APA)
Poon, Myra& Craig, Maria E.& Kaur, Harleen& Cusumano, Janine& Sasongko, Muhammad Bayu& Wong, Tien Yin…[et al.]. 2013. Vitamin D Deficiency Is Not Associated with Changes in Retinal Geometric Parameters in Young People with Type 1 Diabetes. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-459929
Modern Language Association (MLA)
Poon, Myra…[et al.]. Vitamin D Deficiency Is Not Associated with Changes in Retinal Geometric Parameters in Young People with Type 1 Diabetes. Journal of Diabetes Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-459929
American Medical Association (AMA)
Poon, Myra& Craig, Maria E.& Kaur, Harleen& Cusumano, Janine& Sasongko, Muhammad Bayu& Wong, Tien Yin…[et al.]. Vitamin D Deficiency Is Not Associated with Changes in Retinal Geometric Parameters in Young People with Type 1 Diabetes. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-459929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459929