Early Intervention Combined with Targeted Treatment Promotes Cognitive and Behavioral Improvements in Young Children with Fragile X Syndrome
Joint Authors
Schneider, Andrea
Hagerman, Randi J.
Indah Winarni, Tri
Borodyanskara, Mariya
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of the FMR1 gene leading to gene silencing.
Lack of FMRP, a critical protein for dendritic spine formation and maturation, will cause FXS.
Early environmental enrichment combined with pharmacological intervention has been proven to rescue dendritic spine abnormalities in the animal model of FXS.
Here we report on 2 young children with FXS who were treated early with a combination of targeted treatment and intensive educational interventions leading to improvement in their cognition and behavior and a normal IQ.
American Psychological Association (APA)
Indah Winarni, Tri& Schneider, Andrea& Borodyanskara, Mariya& Hagerman, Randi J.. 2012. Early Intervention Combined with Targeted Treatment Promotes Cognitive and Behavioral Improvements in Young Children with Fragile X Syndrome. Case Reports in Genetics،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-459945
Modern Language Association (MLA)
Indah Winarni, Tri…[et al.]. Early Intervention Combined with Targeted Treatment Promotes Cognitive and Behavioral Improvements in Young Children with Fragile X Syndrome. Case Reports in Genetics No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-459945
American Medical Association (AMA)
Indah Winarni, Tri& Schneider, Andrea& Borodyanskara, Mariya& Hagerman, Randi J.. Early Intervention Combined with Targeted Treatment Promotes Cognitive and Behavioral Improvements in Young Children with Fragile X Syndrome. Case Reports in Genetics. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-459945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459945