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17-β-Estradiol Counteracts the Effects of High Frequency Electromagnetic Fields on Trophoblastic Connexins and Integrins
Joint Authors
Lunghi, Laura
Vesce, Fortunato
Cervellati, Franco
Fabbri, Elena
Marci, Roberto
Valbonesi, Paola
Biondi, Carla
Giuseppe, Valacchi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We investigated the effect of high-frequency electromagnetic fields (HF-EMFs) and 17-β-estradiol on connexins (Cxs), integrins (Ints), and estrogen receptor (ER) expression, as well as on ultrastructure of trophoblast-derived HTR-8/SVneo cells.
HF-EMF, 17-β-estradiol, and their combination induced an increase of Cx40 and Cx43 mRNA expression.
HF-EMF decreased Int alpha1 and β1 mRNA levels but enhanced Int alpha5 mRNA expression.
All the Ints mRNA expressions were increased by 17-β-estradiol and exposure to both stimuli.
ER-β mRNA was reduced by HF-EMF but augmented by 17-β-estradiol alone or with HF-EMF.
ER-β immunofluorescence showed a cytoplasmic localization in sham and HF-EMF exposed cells which became nuclear after treatment with hormone or both stimuli.
Electron microscopy evidenced a loss of cellular contact in exposed cells which appeared counteracted by 17-β-estradiol.
We demonstrate that 17-β-estradiol modulates Cxs and Ints as well as ER-β expression induced by HF-EMF, suggesting an influence of both stimuli on trophoblast differentiation and migration.
American Psychological Association (APA)
Cervellati, Franco& Giuseppe, Valacchi& Lunghi, Laura& Fabbri, Elena& Valbonesi, Paola& Marci, Roberto…[et al.]. 2013. 17-β-Estradiol Counteracts the Effects of High Frequency Electromagnetic Fields on Trophoblastic Connexins and Integrins. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-459950
Modern Language Association (MLA)
Cervellati, Franco…[et al.]. 17-β-Estradiol Counteracts the Effects of High Frequency Electromagnetic Fields on Trophoblastic Connexins and Integrins. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-459950
American Medical Association (AMA)
Cervellati, Franco& Giuseppe, Valacchi& Lunghi, Laura& Fabbri, Elena& Valbonesi, Paola& Marci, Roberto…[et al.]. 17-β-Estradiol Counteracts the Effects of High Frequency Electromagnetic Fields on Trophoblastic Connexins and Integrins. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-459950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459950