Screening of α-Glucosidase Inhibitory Activity from Some Plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae

Abstract EN

Diabetes mellitus (DM) is recognized as a serious global health problem that is characterized by high blood sugar levels.

Type 2 DM is more common in diabetic populations.

In this type of DM, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals.

As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a medicine source, including as the α-glucosidase inhibitor.

In this study, we determine the α-glucosidase inhibitory activity of 80% ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae.

Inhibitory activity test of the α-glucosidase was performed in vitro using spectrophotometric methods.

Compared with the control acarbose (IC50 117.20 μg/mL), thirty-seven samples of forty-five were shown to be more potent α-glucosidase inhibitors with IC50 values in the range 2.33–112.02 μg/mL.