![](/images/graphics-bg.png)
Targeting the Tumor Microenvironment : Focus on Angiogenesis
Joint Authors
Jaeger, Dirk
Schimming, Alexander
Fan, Fengjuan
Podar, Klaus
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Tumorigenesis is a complex multistep process involving not only genetic and epigenetic changes in the tumor cell but also selective supportive conditions of the deregulated tumor microenvironment.
One key compartment of the microenvironment is the vascular niche.
The role of angiogenesis in solid tumors but also in hematologic malignancies is now well established.
Research on angiogenesis in general, and vascular endothelial growth factor in particular, is a major focus in biomedicine and has led to the clinical approval of several antiangiogenic agents including thalidomide, bevacizumab, sorafenib, sunitinib, pazopanib, temesirolimus, and everolimus.
Indeed, antiangiogenic agents have significantly changed treatment strategies in solid tumors (colorectal cancer, renal cell carcinoma, and breast cancer) and multiple myeloma.
Here we illustrate important aspects in the interrelationship between tumor cells and the microenvironment leading to tumor progression, with focus on angiogenesis, and summarize derived targeted therapies.
American Psychological Association (APA)
Fan, Fengjuan& Schimming, Alexander& Jaeger, Dirk& Podar, Klaus. 2011. Targeting the Tumor Microenvironment : Focus on Angiogenesis. Journal of Oncology،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-459978
Modern Language Association (MLA)
Fan, Fengjuan…[et al.]. Targeting the Tumor Microenvironment : Focus on Angiogenesis. Journal of Oncology No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-459978
American Medical Association (AMA)
Fan, Fengjuan& Schimming, Alexander& Jaeger, Dirk& Podar, Klaus. Targeting the Tumor Microenvironment : Focus on Angiogenesis. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-459978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459978