Fiber Tracts Anomalies in APPxPS1 Transgenic Mice Modeling Alzheimer's Disease
Joint Authors
Epelbaum, Stéphane
Delatour, Benoît
Chen, H.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Amyloid beta (Aβ) peptides are known to accumulate in the brain of patients with Alzheimer's disease (AD).
However, the link between brain amyloidosis and clinical symptoms has not been elucidated and could be mediated by secondary neuropathological alterations such as fiber tracts anomalies.
In the present study, we have investigated the impact of Aβ overproduction in APPxPS1 transgenic mice on the integrity of forebrain axonal bundles (corpus callosum and anterior commissure).
We found evidence of fiber tract volume reductions in APPxPS1 mice that were associated with an accelerated age-related loss of axonal neurofilaments and a myelin breakdown.
The severity of these defects was neither correlated with the density of amyloid plaques nor associated with cell neurodegeneration.
Our data suggest that commissural fiber tract alterations are present in Aβ-overproducing transgenic mice and that intracellular Aβ accumulation preceding extracellular deposits may act as a trigger of such morphological anomalies.
American Psychological Association (APA)
Chen, H.& Epelbaum, Stéphane& Delatour, Benoît. 2011. Fiber Tracts Anomalies in APPxPS1 Transgenic Mice Modeling Alzheimer's Disease. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-459983
Modern Language Association (MLA)
Chen, H.…[et al.]. Fiber Tracts Anomalies in APPxPS1 Transgenic Mice Modeling Alzheimer's Disease. Journal of Aging Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-459983
American Medical Association (AMA)
Chen, H.& Epelbaum, Stéphane& Delatour, Benoît. Fiber Tracts Anomalies in APPxPS1 Transgenic Mice Modeling Alzheimer's Disease. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-459983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459983