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Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues
Joint Authors
Koorbanally, Neil A.
Reddy, Kandappa H.
Dama, Habila J.
Govender, Patrick
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A series of eleven butanediamine analogues, of which nine were new, were synthesized by the nucleophilic substitution of aromatic amines and benzylamines with maleic anhydride and tested on four yeast strains of Candida species using the broth microdilution method.
Compounds 3a and 3c with an unsubstituted phenyl ring and a 3-methoxyphenyl ring, respectively, are the most active against the fungal species with MIC values ranging from 20.2 to 80.6 μM for C.
albicans and C.
parapsilosis and 178.5 and 161.2 μM for C.
krusei, respectively.
American Psychological Association (APA)
Dama, Habila J.& Reddy, Kandappa H.& Govender, Patrick& Koorbanally, Neil A.. 2013. Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459991
Modern Language Association (MLA)
Dama, Habila J.…[et al.]. Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-459991
American Medical Association (AMA)
Dama, Habila J.& Reddy, Kandappa H.& Govender, Patrick& Koorbanally, Neil A.. Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459991