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Intestinal Type of Lung Adenocarcinoma in Younger Adults
Joint Authors
Subotic, Dragan
Kontic, Milica
Tomasevic, Dragana
Lukic, Jelena
Stojsic, Jelena
Popovic, Marko
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Intestinal type of lung adenocarcinoma (ILADC) was initially described by Tsao and Fraser in 1991.
Morphology and immunophenotype of ILADC are the same as in colorectal adenocarcinoma.
Rectocolonoscopy must be performed to exclude colorectal origin of adenocarcinoma.
Colorectal adenocarcinoma claimed to be genetically similar to an ILADC.
Patients.
We describe 24- and 26-year-old patients of both genders who went under surgery because of a lung tumor mass detected on CT scan.
ILADC was diagnosed on resected lung specimens.
According to positivity of Cytokeratin20, CDX-2, and Villin, respectively, and negativity of Cytokeratin7, TTF-1, Napsin-A, SurfactantB, MUC-1, and MUC-2, respectively, ILADC was diagnosed.
KRAS mutation was detected in tumor tissue of the male patient.
Conclusion.
Rectocolonoscopy is the only relevant method for distinguishing the intestinal type of lung adenocarcinoma from metastatic colorectal carcinoma because immunohistochemistry and detection of mutation status are frequently the same in both types of adenocarcinoma.
More investigations are needed for further understanding of ILADC in purpose of personalized lung carcinoma therapy particularly introducing detection of mutation status, especially in younger patients.
American Psychological Association (APA)
Stojsic, Jelena& Kontic, Milica& Subotic, Dragan& Popovic, Marko& Tomasevic, Dragana& Lukic, Jelena. 2014. Intestinal Type of Lung Adenocarcinoma in Younger Adults. Case Reports in Pulmonology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-460086
Modern Language Association (MLA)
Stojsic, Jelena…[et al.]. Intestinal Type of Lung Adenocarcinoma in Younger Adults. Case Reports in Pulmonology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-460086
American Medical Association (AMA)
Stojsic, Jelena& Kontic, Milica& Subotic, Dragan& Popovic, Marko& Tomasevic, Dragana& Lukic, Jelena. Intestinal Type of Lung Adenocarcinoma in Younger Adults. Case Reports in Pulmonology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-460086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460086