Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms
Joint Authors
Wang, Deqing
Ying, Mingzhong
Tian, Yaping
Thomas, Graham Neil
Tomlinson, Brian
Zhuang, Yuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Astragalus mongholicus Bunge has long been used to treat cardiovascular disease in Chinese traditional medicine.
However, its mechanisms are not fully understood.
In this study, we explored potential mechanisms and protective effects of total flavonoids of Astragalus (TFA) on cardiovascular disease using in vitro experiments and diet-induced atherosclerotic rabbits.
We identified six components and their proportion in TFA.
The animal experiments showed that TFA significantly reduced plasma levels of total cholesterol and LDL cholesterol (P<0.05 to 0.01), increased HDL cholesterol levels (P<0.01), and reduced the aortic fatty streak area by 43.6 to 63.6% (P<0.01).
We also found that TFA scavenged superoxide and hydroxyl radicals and this effect increased with higher TFA concentration.
In in vivo experiments, TFA effectively inhibited the free radical spectrum in the ischemia-reperfusion module.
In conclusion, TFA was the active component of Astragalus mongholicus Bunge, which benefits cardiovascular disease attributing to the potent antioxidant activity to improve the atherosclerosis profile.
American Psychological Association (APA)
Wang, Deqing& Zhuang, Yuan& Tian, Yaping& Thomas, Graham Neil& Ying, Mingzhong& Tomlinson, Brian. 2012. Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460101
Modern Language Association (MLA)
Wang, Deqing…[et al.]. Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-460101
American Medical Association (AMA)
Wang, Deqing& Zhuang, Yuan& Tian, Yaping& Thomas, Graham Neil& Ying, Mingzhong& Tomlinson, Brian. Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460101