Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology
Joint Authors
Gentric, Géraldine
Celton-Morizur, Séverine
Desdouets, Chantal
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Most cells in mammalian tissues usually contain a diploid complement of chromosomes.
However, numerous studies have demonstrated a major role of “diploid-polyploid conversion” during physiopathological processes in several tissues.
In the liver parenchyma, progressive polyploidization of hepatocytes takes place during postnatal growth.
Indeed, at the suckling-weaning transition, cytokinesis failure events induce the genesis of binucleated tetraploid liver cells.
Insulin signalling, through regulation of the PI3K/Akt signalling pathway, is essential in the establishment of liver tetraploidization by controlling cytoskeletal organisation and consequently mitosis progression.
Liver cell polyploidy is generally considered to indicate terminal differentiation and senescence, and both lead to a progressive loss of cell pluripotency associated to a markedly decreased replication capacity.
Although adult liver is a quiescent organ, it retains a capacity to proliferate and to modulate its ploidy in response to various stimuli or aggression (partial hepatectomy, metabolic overload (i.e., high copper and iron hepatic levels), oxidative stress, toxic insult, and chronic hepatitis etc.).
Here we review the mechanisms and functional consequences of hepatocytes polyploidization during normal and pathological liver growth.
American Psychological Association (APA)
Gentric, Géraldine& Desdouets, Chantal& Celton-Morizur, Séverine. 2012. Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-460106
Modern Language Association (MLA)
Gentric, Géraldine…[et al.]. Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology. International Journal of Hepatology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-460106
American Medical Association (AMA)
Gentric, Géraldine& Desdouets, Chantal& Celton-Morizur, Séverine. Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-460106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460106