Administration of the Resveratrol Analogues Isorhapontigenin and Heyneanol-A Protects Mice Hematopoietic Cells against Irradiation Injuries
Joint Authors
Zhang, Heng
Yan, Hao
Zhang, Chun-ze
Yang, Yi-ling
Wu, Xiao-jing
Wang, Hui
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ionizing radiation (IR) is known not only to cause acute bone marrow (BM) suppression but also to lead to long-term residual hematopoietic injury.
These effects have been attributed to IR inducing the generation of reactive oxygen species (ROS) in hematopoietic cells.
In this study, we examined if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression.
The results of cell viability assays, clonogenic assays, and competitive repopulation assays revealed that treatment with these compounds could protect mice BM mononuclear cells (BMMNC), hematopoietic progenitor cells, and hematopoietic stem cells from IR-induced BM suppression.
Moreover, the expression of genes related to the endogenous cellular antioxidant system in hematopoietic cells was analyzed.
The expression and activity of SOD2 and GPX1 were found to be decreased in irradiated BMMNC, and the application of the resveratrol analogues could ameliorate this damage.
Our results suggest that in comparison with resveratrol and isorhapontigenin, treatment with heyneanol-A can protect hematopoietic cells from IR-induced damage to a greater degree; the protective effects of these compounds are probably the result of their antioxidant properties.
American Psychological Association (APA)
Wang, Hui& Yang, Yi-ling& Zhang, Heng& Yan, Hao& Wu, Xiao-jing& Zhang, Chun-ze. 2014. Administration of the Resveratrol Analogues Isorhapontigenin and Heyneanol-A Protects Mice Hematopoietic Cells against Irradiation Injuries. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-460125
Modern Language Association (MLA)
Wang, Hui…[et al.]. Administration of the Resveratrol Analogues Isorhapontigenin and Heyneanol-A Protects Mice Hematopoietic Cells against Irradiation Injuries. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-460125
American Medical Association (AMA)
Wang, Hui& Yang, Yi-ling& Zhang, Heng& Yan, Hao& Wu, Xiao-jing& Zhang, Chun-ze. Administration of the Resveratrol Analogues Isorhapontigenin and Heyneanol-A Protects Mice Hematopoietic Cells against Irradiation Injuries. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-460125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460125