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Macrophage Autophagy and Oxidative Stress : An Ultrastructural and Immunoelectron Microscopical Study
Joint Authors
Perrotta, Ida
Russo, Emilio
Donato, Giuseppe
Tripepi, Sandro
Aquila, Saveria
Carito, Valentina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The word autophagy broadly refers to the cellular catabolic processes that lead to the removal of damaged cytosolic proteins or cell organelles through lysosomes.
Although autophagy is often observed during programmed cell death, it may also serve as a cell survival mechanism.
Accumulation of reactive oxygen species within tissues and cells induces various defense mechanisms or programmed cell death.
It has been shown that, besides inducing apoptosis, oxidative stress can also induce autophagy.
To date, however, the regulation of autophagy in response to oxidative stress remains largely elusive and poorly understood.
Therefore, the present study was designed to examine the ratio between oxidative stress and autophagy in macrophages after oxidant exposure (AAPH) and to investigate the ultrastructural localization of beclin-1, a protein essential for autophagy, under basal and stressful conditions.
Our data provide evidence that oxidative stress induces autophagy in macrophages.
We demonstrate, for the first time by immunoelectron microscopy, the subcellular localization of beclin-1 in autophagic cells.
American Psychological Association (APA)
Perrotta, Ida& Carito, Valentina& Russo, Emilio& Tripepi, Sandro& Aquila, Saveria& Donato, Giuseppe. 2011. Macrophage Autophagy and Oxidative Stress : An Ultrastructural and Immunoelectron Microscopical Study. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-460130
Modern Language Association (MLA)
Perrotta, Ida…[et al.]. Macrophage Autophagy and Oxidative Stress : An Ultrastructural and Immunoelectron Microscopical Study. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-460130
American Medical Association (AMA)
Perrotta, Ida& Carito, Valentina& Russo, Emilio& Tripepi, Sandro& Aquila, Saveria& Donato, Giuseppe. Macrophage Autophagy and Oxidative Stress : An Ultrastructural and Immunoelectron Microscopical Study. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-460130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460130