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The Role of RUNX2 in Osteosarcoma Oncogenesis
Joint Authors
Zielenska, Maria
Stein, Gary S.
van Wijnen, A. J.
Squire, Jeremy A.
Martin, Jeff W.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents.
Its rarity and biological heterogeneity have limited studies of its molecular basis.
In recent years, an important role has emerged for the RUNX2 “platform protein” in osteosarcoma oncogenesis.
RUNX proteins are DNA-binding transcription factors that regulate the expression of multiple genes involved in cellular differentiation and cell-cycle progression.
RUNX2 is genetically essential for developing bone and osteoblast maturation.
Studies of osteosarcoma tumours have revealed that the RUNX2 DNA copy number together with RNA and protein levels are highly elevated in osteosarcoma tumors.
The protein is also important for metastatic bone disease of prostate and breast cancers, while RUNX2 may have both tumor suppressive and oncogenic roles in bone morphogenesis.
This paper provides a synopsis of the current understanding of the functions of RUNX2 and its potential role in osteosarcoma and suggests directions for future study.
American Psychological Association (APA)
Martin, Jeff W.& Zielenska, Maria& Stein, Gary S.& van Wijnen, A. J.& Squire, Jeremy A.. 2010. The Role of RUNX2 in Osteosarcoma Oncogenesis. Sarcoma،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-460131
Modern Language Association (MLA)
Martin, Jeff W.…[et al.]. The Role of RUNX2 in Osteosarcoma Oncogenesis. Sarcoma No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-460131
American Medical Association (AMA)
Martin, Jeff W.& Zielenska, Maria& Stein, Gary S.& van Wijnen, A. J.& Squire, Jeremy A.. The Role of RUNX2 in Osteosarcoma Oncogenesis. Sarcoma. 2010. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-460131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460131