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An ANOCEF Genomic and Transcriptomic Microarray Study of the Response to Irinotecan and Bevacizumab in Recurrent Glioblastomas
Joint Authors
Vintonenko, Nadia
Gallego Perez-Larraya, Jaime
Idbaih, Ahmed
Farina, Patrizia
Boisselier, Blandine
Figarella-Branger, Dominique
Chinot, Olivier
Anna Luisa Di, Stefano
Delattre, Jean-Yves
Sanson, Marc
Honnorat, Jérôme
Marie, Yannick
Laffaire, Julien
Ducray, François
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
We performed a retrospective study to assess whether the initial molecular characteristics of glioblastomas (GBMs) were associated with the response to the bevacizumab/irinotecan chemotherapy regimen given at recurrence.
Results.
Comparison of the genomic and gene expression profiles of the responders (n=12) and nonresponders (n=13) demonstrated only slight differences and could not identify any robust biomarkers associated with the response.
In contrast, a significant association was observed between GBMs molecular subtypes and response rates.
GBMs assigned to molecular subtype IGS-18 and to classical subtype had a lower response rate than those assigned to other subtypes.
In an independent series of 33 patients, neither EGFR amplification nor CDKN2A deletion (which are frequent in IGS-18 and classical GBMs) was significantly associated with the response rate, suggesting that these two alterations are unlikely to explain the lower response rate of these GBMs molecular subtypes.
Conclusion.
Despite its limited sample size, the present study suggests that comparing the initial molecular profiles of responders and nonresponders might not be an effective strategy to identify biomarkers of the response to bevacizumab given at recurrence.
Yet it suggests that the response rate might differ among GBMs molecular subtypes.
American Psychological Association (APA)
Laffaire, Julien& Anna Luisa Di, Stefano& Chinot, Olivier& Idbaih, Ahmed& Gallego Perez-Larraya, Jaime& Marie, Yannick…[et al.]. 2014. An ANOCEF Genomic and Transcriptomic Microarray Study of the Response to Irinotecan and Bevacizumab in Recurrent Glioblastomas. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460138
Modern Language Association (MLA)
Laffaire, Julien…[et al.]. An ANOCEF Genomic and Transcriptomic Microarray Study of the Response to Irinotecan and Bevacizumab in Recurrent Glioblastomas. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-460138
American Medical Association (AMA)
Laffaire, Julien& Anna Luisa Di, Stefano& Chinot, Olivier& Idbaih, Ahmed& Gallego Perez-Larraya, Jaime& Marie, Yannick…[et al.]. An ANOCEF Genomic and Transcriptomic Microarray Study of the Response to Irinotecan and Bevacizumab in Recurrent Glioblastomas. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-460138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460138