Intracranial Atherosclerotic Disease
Joint Authors
Naqvi, Imama
Bansari, Asha
Kamal, Ayeesha Kamran
Khan, Maria
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Intracranial atherosclerotic disease (ICAD) is the most common proximate mechanism of ischemic stroke worldwide.
Approximately half of those affected are Asians.
For diagnosis of ICAD, intra-arterial angiography is the gold standard to identify extent of stenosis.
However, noninvasive techniques including transcranial ultrasound and MRA are now emerging as reliable modalities to exclude moderate to severe (50%–99%) stenosis.
Little is known about measures for primary prevention of the disease.
In terms of secondary prevention of stroke due to intracranial atherosclerotic stenosis, aspirin continues to be the preferred antiplatelet agent although clopidogrel along with aspirin has shown promise in the acute phase.
Among Asians, cilostazol has shown a favorable effect on symptomatic stenosis and is of benefit in terms of fewer bleeds.
Moreover, aggressive risk factor management alone and in combination with dual antiplatelets been shown to be most effective in this group of patients.
Interventional trials on intracranial atherosclerotic stenosis have so far only been carried out among Caucasians and have not yielded consistent results.
Since the Asian population is known to be preferentially effected, focused trials need to be performed to establish treatment modalities that are most effective in this population.
American Psychological Association (APA)
Khan, Maria& Naqvi, Imama& Bansari, Asha& Kamal, Ayeesha Kamran. 2011. Intracranial Atherosclerotic Disease. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-460140
Modern Language Association (MLA)
Khan, Maria…[et al.]. Intracranial Atherosclerotic Disease. Stroke Research and Treatment No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-460140
American Medical Association (AMA)
Khan, Maria& Naqvi, Imama& Bansari, Asha& Kamal, Ayeesha Kamran. Intracranial Atherosclerotic Disease. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-460140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460140