Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha
Joint Authors
Wolf, Cynthia J.
Schmid, Judith R.
Zehr, Robert D.
Abbott, Barbara D.
Lau, Christopher S.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Perfluorononanoic acid (PFNA) is one of the perfluoroalkyl acids found in the environment and in tissues of humans and wildlife.
Prenatal exposure to PFNA negatively impacts survival and development of mice and activates the mouse and human peroxisome proliferator-activated receptor-alpha (PPARα).
In the current study, we used PPARα knockout (KO) and 129S1/SvlmJ wild-type (WT) mice to investigate the role of PPARα in mediating PFNA-induced in vivo effects.
Pregnant KO and WT mice were dosed orally with water (vehicle control: 10 ml/kg), 0.83, 1.1, 1.5, or 2 mg/kg PFNA on gestational days (GDs) 1–18 (day of sperm plug = GD 0).
Maternal weight gain, implantation, litter size, and pup weight at birth were unaffected in either strain.
PFNA exposure reduced the number of live pups at birth and survival of offspring to weaning in the 1.1 and 2 mg/kg groups in WT.
Eye opening was delayed (mean delay 2.1 days) and pup weight at weaning was reduced in WT pups at 2 mg/kg.
These developmental endpoints were not affected in the KO.
Relative liver weight was increased in a dose-dependent manner in dams and pups of the WT strain at all dose levels but only slightly increased in the highest dose group in the KO strain.
In summary, PFNA altered liver weight of dams and pups, pup survival, body weight, and development in the WT, while only inducing a slight increase in relative liver weight of dams and pups at 2 mg/kg in KO mice.
These results suggest that PPARα is an essential mediator of PFNA-induced developmental toxicity in the mouse.
American Psychological Association (APA)
Wolf, Cynthia J.& Zehr, Robert D.& Schmid, Judith R.& Lau, Christopher S.& Abbott, Barbara D.. 2010. Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha. PPAR Research،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-460144
Modern Language Association (MLA)
Wolf, Cynthia J.…[et al.]. Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha. PPAR Research No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-460144
American Medical Association (AMA)
Wolf, Cynthia J.& Zehr, Robert D.& Schmid, Judith R.& Lau, Christopher S.& Abbott, Barbara D.. Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-460144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460144