Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds
Joint Authors
Oliveira, Dhelfeson Willya Douglas
Abreu, Andreza Miranda
Lima, Nádia Lages
Marinho, Sandra Aparecida
de Miranda, João Luiz
Verli, Flaviana Dornela
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Fibroblasts on the edges of a surgical wound are induced to synthesize collagen during the healing process which is known as fibroplasia.
Objective.
The aim of this study was to determine the effect of the application of different substances on fibroplasia of cutaneous surgical wounds on rats.
Materials and Methods.
48 Wistar rats were divided into three groups.
A surgical wound 1 cm in diameter and 1 mm in depth was created on the dorsum of each animal.
The surgical wounds were submitted to the topical application of an alcoholic extract of 30% propolis, 70% alcohol, or 0.001% dexamethasone in a cream base every 12 hours.
The animals were sacrificed three, seven, 14, and 28 days postoperatively.
The specimens were histologically processed and stained with Masson’s trichrome.
The assessment of fibroplasia was performed using a scoring system: (1) 5 to 25% collagen deposition; (2) 26 to 50% collagen deposition; (3) 51 to 75% collagen deposition; (4) more than 75% collagen deposition.
Results.
There were statistically significant differences in collagen deposition between the substances at all postoperative evaluation times.
Conclusion.
Propolis and alcohol promoted greater collagen deposition in surgical wounds than dexamethasone.
American Psychological Association (APA)
Abreu, Andreza Miranda& Oliveira, Dhelfeson Willya Douglas& Marinho, Sandra Aparecida& Lima, Nádia Lages& de Miranda, João Luiz& Verli, Flaviana Dornela. 2012. Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds. ISRN Dermatology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-460151
Modern Language Association (MLA)
Abreu, Andreza Miranda…[et al.]. Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds. ISRN Dermatology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-460151
American Medical Association (AMA)
Abreu, Andreza Miranda& Oliveira, Dhelfeson Willya Douglas& Marinho, Sandra Aparecida& Lima, Nádia Lages& de Miranda, João Luiz& Verli, Flaviana Dornela. Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds. ISRN Dermatology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-460151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460151