Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds

Joint Authors

Oliveira, Dhelfeson Willya Douglas
Abreu, Andreza Miranda
Lima, Nádia Lages
Marinho, Sandra Aparecida
de Miranda, João Luiz
Verli, Flaviana Dornela

Source

ISRN Dermatology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-03-29

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases

Abstract EN

Background.

Fibroblasts on the edges of a surgical wound are induced to synthesize collagen during the healing process which is known as fibroplasia.

Objective.

The aim of this study was to determine the effect of the application of different substances on fibroplasia of cutaneous surgical wounds on rats.

Materials and Methods.

48 Wistar rats were divided into three groups.

A surgical wound 1 cm in diameter and 1 mm in depth was created on the dorsum of each animal.

The surgical wounds were submitted to the topical application of an alcoholic extract of 30% propolis, 70% alcohol, or 0.001% dexamethasone in a cream base every 12 hours.

The animals were sacrificed three, seven, 14, and 28 days postoperatively.

The specimens were histologically processed and stained with Masson’s trichrome.

The assessment of fibroplasia was performed using a scoring system: (1) 5 to 25% collagen deposition; (2) 26 to 50% collagen deposition; (3) 51 to 75% collagen deposition; (4) more than 75% collagen deposition.

Results.

There were statistically significant differences in collagen deposition between the substances at all postoperative evaluation times.

Conclusion.

Propolis and alcohol promoted greater collagen deposition in surgical wounds than dexamethasone.

American Psychological Association (APA)

Abreu, Andreza Miranda& Oliveira, Dhelfeson Willya Douglas& Marinho, Sandra Aparecida& Lima, Nádia Lages& de Miranda, João Luiz& Verli, Flaviana Dornela. 2012. Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds. ISRN Dermatology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-460151

Modern Language Association (MLA)

Abreu, Andreza Miranda…[et al.]. Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds. ISRN Dermatology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-460151

American Medical Association (AMA)

Abreu, Andreza Miranda& Oliveira, Dhelfeson Willya Douglas& Marinho, Sandra Aparecida& Lima, Nádia Lages& de Miranda, João Luiz& Verli, Flaviana Dornela. Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds. ISRN Dermatology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-460151

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-460151