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An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans
Joint Authors
Haupt, Axel
Machicao, Fausto
Häring, Hans-Ulrich
Ketterer, Caroline
Hennige, Anita M.
Fritsche, Andreas
Preissl, Hubert
Tschritter, Otto
Sartorius, Tina
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-03
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Activation of melanocortin-4 receptor (MC4R) by insulin sensitive neurons is a central mechanism in body weight regulation, and genetic variants in the MC4R gene (e.g., rs17782313) are associated with obesity.
By using magnetoencephalography, we addressed whether rs17782313 affects the cerebrocortical insulin response.
We measured the cerebrocortical insulin response by using magnetoencephalography in a hyperinsulinemic euglycemic clamp (versus placebo) in 51 nondiabetic humans (26 f/25 m, age 35±3 years, BMI 28±1 kg/m2).
The C-allele of rs17782313 was minor allele (frequency 23%), and the genotype distribution (TT 30, TC 19, CC 2) was in Hardy-Weinberg-Equilibrium.
Insulin-stimulated cerebrocortical theta activity was decreased in the presence of the C-allele (TT 33±16 fT; TC/CC −27±20 fT; P=.023), and this effect remained significant after adjusting for BMI and peripheral insulin sensitivity (P=.047).
Cerebrocortical theta activity was impaired in carriers of the obesity risk allele.
Therefore, cerebral insulin resistance may contribute to the obesity effect of rs17782313.
American Psychological Association (APA)
Tschritter, Otto& Haupt, Axel& Preissl, Hubert& Ketterer, Caroline& Hennige, Anita M.& Sartorius, Tina…[et al.]. 2011. An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans. Journal of Obesity،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-460167
Modern Language Association (MLA)
Tschritter, Otto…[et al.]. An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans. Journal of Obesity No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-460167
American Medical Association (AMA)
Tschritter, Otto& Haupt, Axel& Preissl, Hubert& Ketterer, Caroline& Hennige, Anita M.& Sartorius, Tina…[et al.]. An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans. Journal of Obesity. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-460167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460167