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Integrin Signaling in Cancer Cell Survival and Chemoresistance
Joint Authors
Aoudjit, Fawzi
Vuori, Kristiina
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Resistance to apoptosis and chemotherapy is a hallmark of cancer cells, and it is a critical factor in cancer recurrence and patient relapse.
Extracellular matrix (ECM) via its receptors, the integrins, has emerged as a major pathway contributing to cancer cell survival and resistance to chemotherapy.
Several studies over the last decade have demonstrated that ECM/integrin signaling provides a survival advantage to various cancer cell types against numerous chemotherapeutic drugs and against antibody therapy.
In this paper, we will discuss the major findings on how ECM/integrin signaling protects tumor cells from drug-induced apoptosis.
We will also discuss the potential role of ECM in malignant T-cell survival and in cancer stem cell resistance.
Understanding how integrins and their signaling partners promote tumor cell survival and chemoresistance will likely lead to the development of new therapeutic strategies and agents for cancer treatment.
American Psychological Association (APA)
Aoudjit, Fawzi& Vuori, Kristiina. 2012. Integrin Signaling in Cancer Cell Survival and Chemoresistance. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-460171
Modern Language Association (MLA)
Aoudjit, Fawzi& Vuori, Kristiina. Integrin Signaling in Cancer Cell Survival and Chemoresistance. Chemotherapy Research and Practice No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-460171
American Medical Association (AMA)
Aoudjit, Fawzi& Vuori, Kristiina. Integrin Signaling in Cancer Cell Survival and Chemoresistance. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-460171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460171