Evaluation and Clinical Validity of a New Questionnaire for Mikulicz's Disease
Joint Authors
Tabeya, Tetsuya
Yajima, Hidetaka
Yamamoto, Hiroyuki
Naishiro, Yasuyoshi
Takahashi, Hiroki
Suzuki, Chisako
Shinomura, Yasuhisa
Imai, Kohzoh
Ishigami, Keisuke
Shimizu, Yui
Matsui, Mikiko
Yamamoto, Motohisa
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
The characteristic features of Mikulicz’s disease (MD) are diffuse enlargement of the lacrimal and submandibular glands, elevated levels of serum immunoglobulin (Ig)G4, and abundant infiltration of IgG4-positive plasmacytes into both glands.
No disease index is available to properly evaluate MD, so we developed a functional assessment of MD, the Mikulicz’s disease activity questionnaire (MAQ), and evaluated its clinical efficacy.
Methods.
We selected 18 patients who were either being treated for MD or who had presented with recurrence.
The patients completed a self-assessment and were scored according to the MAQ sheet during each visit between December 2009 and August 2011.
Assessment items were in regard to increases or decreases in lacrimal and salivary gland enlargement and severity of sicca symptoms.
Results.
On the first visits, MAQ scores were high, but scores decreased rapidly as treatment progressed.
When doses of glucocorticoid were reduced, some patients showed increased scores.
Dry-symptom scores increased initially.
MAQ scores for patients with recurrent MD gradually increased over several months before relapse.
However, some patients displayed no elevation in MAQ scores due to relapses at other sites.
Conclusion.
MAQ score can be used to quantify flares and treatment response and is useful for functional assessment of MD.
American Psychological Association (APA)
Yamamoto, Motohisa& Takahashi, Hiroki& Ishigami, Keisuke& Yajima, Hidetaka& Shimizu, Yui& Tabeya, Tetsuya…[et al.]. 2012. Evaluation and Clinical Validity of a New Questionnaire for Mikulicz's Disease. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-460184
Modern Language Association (MLA)
Yamamoto, Motohisa…[et al.]. Evaluation and Clinical Validity of a New Questionnaire for Mikulicz's Disease. International Journal of Rheumatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-460184
American Medical Association (AMA)
Yamamoto, Motohisa& Takahashi, Hiroki& Ishigami, Keisuke& Yajima, Hidetaka& Shimizu, Yui& Tabeya, Tetsuya…[et al.]. Evaluation and Clinical Validity of a New Questionnaire for Mikulicz's Disease. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-460184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460184